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Distribution patterns of five indictors between occult and overt HBV infection groups in the training and validation set Comparison of the five OBI-related indicators between occult and overt HBV infection groups in both the training (left) and validation (right) sets (A) Age, (B) HBV DNA Ct value, (C) Anti-HBs titer, <t>(D)</t> <t>Anti-HBc</t> level, and (E) Anti-HBe status. Data for continuous indicators (A–D) are presented as median with IQR in box plots. (E) displays the proportion of anti-HBe negative cases as a bar chart. Statistical comparisons for continuous variables were performed using the Mann-Whitney U test, and for anti-HBe status using Fisher’s exact test. Exact p values are reported directly. HBV DNA Ct value of 60 was assigned to samples with undetectable viral loads.
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Distribution patterns of five indictors between occult and overt HBV infection groups in the training and validation set Comparison of the five OBI-related indicators between occult and overt HBV infection groups in both the training (left) and validation (right) sets (A) Age, (B) HBV DNA Ct value, (C) Anti-HBs titer, <t>(D)</t> <t>Anti-HBc</t> level, and (E) Anti-HBe status. Data for continuous indicators (A–D) are presented as median with IQR in box plots. (E) displays the proportion of anti-HBe negative cases as a bar chart. Statistical comparisons for continuous variables were performed using the Mann-Whitney U test, and for anti-HBe status using Fisher’s exact test. Exact p values are reported directly. HBV DNA Ct value of 60 was assigned to samples with undetectable viral loads.
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Distribution patterns of five indictors between occult and overt HBV infection groups in the training and validation set Comparison of the five OBI-related indicators between occult and overt HBV infection groups in both the training (left) and validation (right) sets (A) Age, (B) HBV DNA Ct value, (C) Anti-HBs titer, <t>(D)</t> <t>Anti-HBc</t> level, and (E) Anti-HBe status. Data for continuous indicators (A–D) are presented as median with IQR in box plots. (E) displays the proportion of anti-HBe negative cases as a bar chart. Statistical comparisons for continuous variables were performed using the Mann-Whitney U test, and for anti-HBe status using Fisher’s exact test. Exact p values are reported directly. HBV DNA Ct value of 60 was assigned to samples with undetectable viral loads.
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Distribution patterns of five indictors between occult and overt HBV infection groups in the training and validation set Comparison of the five OBI-related indicators between occult and overt HBV infection groups in both the training (left) and validation (right) sets (A) Age, (B) HBV DNA Ct value, (C) Anti-HBs titer, <t>(D)</t> <t>Anti-HBc</t> level, and (E) Anti-HBe status. Data for continuous indicators (A–D) are presented as median with IQR in box plots. (E) displays the proportion of anti-HBe negative cases as a bar chart. Statistical comparisons for continuous variables were performed using the Mann-Whitney U test, and for anti-HBe status using Fisher’s exact test. Exact p values are reported directly. HBV DNA Ct value of 60 was assigned to samples with undetectable viral loads.
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Distribution patterns of five indictors between occult and overt HBV infection groups in the training and validation set Comparison of the five OBI-related indicators between occult and overt HBV infection groups in both the training (left) and validation (right) sets (A) Age, (B) HBV DNA Ct value, (C) Anti-HBs titer, <t>(D)</t> <t>Anti-HBc</t> level, and (E) Anti-HBe status. Data for continuous indicators (A–D) are presented as median with IQR in box plots. (E) displays the proportion of anti-HBe negative cases as a bar chart. Statistical comparisons for continuous variables were performed using the Mann-Whitney U test, and for anti-HBe status using Fisher’s exact test. Exact p values are reported directly. HBV DNA Ct value of 60 was assigned to samples with undetectable viral loads.
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Distribution patterns of five indictors between occult and overt HBV infection groups in the training and validation set Comparison of the five OBI-related indicators between occult and overt HBV infection groups in both the training (left) and validation (right) sets (A) Age, (B) HBV DNA Ct value, (C) Anti-HBs titer, <t>(D)</t> <t>Anti-HBc</t> level, and (E) Anti-HBe status. Data for continuous indicators (A–D) are presented as median with IQR in box plots. (E) displays the proportion of anti-HBe negative cases as a bar chart. Statistical comparisons for continuous variables were performed using the Mann-Whitney U test, and for anti-HBe status using Fisher’s exact test. Exact p values are reported directly. HBV DNA Ct value of 60 was assigned to samples with undetectable viral loads.
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Distribution patterns of five indictors between occult and overt HBV infection groups in the training and validation set Comparison of the five OBI-related indicators between occult and overt HBV infection groups in both the training (left) and validation (right) sets (A) Age, (B) HBV DNA Ct value, (C) Anti-HBs titer, <t>(D)</t> <t>Anti-HBc</t> level, and (E) Anti-HBe status. Data for continuous indicators (A–D) are presented as median with IQR in box plots. (E) displays the proportion of anti-HBe negative cases as a bar chart. Statistical comparisons for continuous variables were performed using the Mann-Whitney U test, and for anti-HBe status using Fisher’s exact test. Exact p values are reported directly. HBV DNA Ct value of 60 was assigned to samples with undetectable viral loads.
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Distribution patterns of five indictors between occult and overt HBV infection groups in the training and validation set Comparison of the five OBI-related indicators between occult and overt HBV infection groups in both the training (left) and validation (right) sets (A) Age, (B) HBV DNA Ct value, (C) Anti-HBs titer, (D) Anti-HBc level, and (E) Anti-HBe status. Data for continuous indicators (A–D) are presented as median with IQR in box plots. (E) displays the proportion of anti-HBe negative cases as a bar chart. Statistical comparisons for continuous variables were performed using the Mann-Whitney U test, and for anti-HBe status using Fisher’s exact test. Exact p values are reported directly. HBV DNA Ct value of 60 was assigned to samples with undetectable viral loads.

Journal: iScience

Article Title: HBV biomarkers outperform host genetic variants in distinguishing occult HBV infection from chronic carriers

doi: 10.1016/j.isci.2026.115650

Figure Lengend Snippet: Distribution patterns of five indictors between occult and overt HBV infection groups in the training and validation set Comparison of the five OBI-related indicators between occult and overt HBV infection groups in both the training (left) and validation (right) sets (A) Age, (B) HBV DNA Ct value, (C) Anti-HBs titer, (D) Anti-HBc level, and (E) Anti-HBe status. Data for continuous indicators (A–D) are presented as median with IQR in box plots. (E) displays the proportion of anti-HBe negative cases as a bar chart. Statistical comparisons for continuous variables were performed using the Mann-Whitney U test, and for anti-HBe status using Fisher’s exact test. Exact p values are reported directly. HBV DNA Ct value of 60 was assigned to samples with undetectable viral loads.

Article Snippet: ARCHITECT immunoassays (for anti-HBs, HBeAg, anti-HBe, anti-HBc) , Abbott Ireland Diagnostics Division, Sligo, Ireland , N/A.

Techniques: Infection, Biomarker Discovery, Comparison, MANN-WHITNEY

Distribution patterns of indicators between OBI and overt HBV infection groups in unvaccinated and vaccinated groups Stratified analysis of the five indicators by HBV vaccination status (A) Age, (B) HBV DNA Ct value, (C) Anti-HBs titer, (D) Anti-HBc level, and (E) Anti-HBe status. Data for continuous indicators (A–D) are presented as median with IQR in box plots. (E) displays the proportion of anti-HBe negative cases as a bar chart. Data for continuous indicators are presented as median with IQR. Statistical comparisons between OBI and overt groups within each vaccination stratum were performed using the Mann-Whitney U test for continuous variables and Fisher’s exact test for anti-HBe status.

Journal: iScience

Article Title: HBV biomarkers outperform host genetic variants in distinguishing occult HBV infection from chronic carriers

doi: 10.1016/j.isci.2026.115650

Figure Lengend Snippet: Distribution patterns of indicators between OBI and overt HBV infection groups in unvaccinated and vaccinated groups Stratified analysis of the five indicators by HBV vaccination status (A) Age, (B) HBV DNA Ct value, (C) Anti-HBs titer, (D) Anti-HBc level, and (E) Anti-HBe status. Data for continuous indicators (A–D) are presented as median with IQR in box plots. (E) displays the proportion of anti-HBe negative cases as a bar chart. Data for continuous indicators are presented as median with IQR. Statistical comparisons between OBI and overt groups within each vaccination stratum were performed using the Mann-Whitney U test for continuous variables and Fisher’s exact test for anti-HBe status.

Article Snippet: ARCHITECT immunoassays (for anti-HBs, HBeAg, anti-HBe, anti-HBc) , Abbott Ireland Diagnostics Division, Sligo, Ireland , N/A.

Techniques: Infection, MANN-WHITNEY